Indinavir-induced neuropathy may result in erectile dysfunction. Leukocyturia, crystalluria, and dysuria have been reported during postmarketing experience. Elderly: Use with caution in elderly patients. Dosage adjustment recommended in patients with hepatic impairment due to cirrhosis. 1 See Hepatic Impairment under Dosage and Administration. Advise patients that if a dose is missed, take the next dose at regularly scheduled time. 1 Do not take a double dose to make up for the missed dose.
Dose to be repeated no earlier than 3 days. Following 1-hour IV infusion. Suvorexant: CYP3A4 Inhibitors Strong may increase the serum concentration of Suvorexant. Reyataz atazanavir sulfate US prescribing information.
ZERIT stavudine is peripheral neuropathy. Prophylaxis should be initiated immediately, preferably within hours after exposure. What other drugs will affect indinavir? Dose reduction of Crixivan to 600 mg every 8 hours is recommended when administering ketoconazole concurrently.
Unadkat JD, Wara DW, Hughes MD, et al. "Pharmacokinetics and safety of indinavir in human immunodeficiency virus-infected pregnant women. Procoralan ivabradine hydrochloride summary of product characteristics. Les Laboratoires Servier March, 2015. Drug interaction studies were performed with Crixivan and other drugs likely to be coadministered and some drugs commonly used as probes for pharmacokinetic interactions. The effects of coadministration of Crixivan on the AUC, C max and C min are summarized in effect of other drugs on indinavir and effect of indinavir on other drugs. For information regarding clinical recommendations, see in PRECAUTIONS.
Gerberding JL. Prophylaxis for occupational exposure to HIV. Ann Intern Med. AtorvaSTATin: Protease Inhibitors may increase the serum concentration of AtorvaSTATin. Management: See full monograph for recommended dose limits. Tremblay C, Merrill DP, Chou TC et al. Interactions among combinations of two and three protease inhibitors against drug-susceptible and drug-resistant HIV-1 isolates. J Acquir Immune Defic Syndr. Keep taking indinavir for the full time of treatment, even if you begin to feel better. CRIXIVAN Capsules are sensitive to moisture. Consider discontinuing indinavir in patients with severe leukocyturia. Invirase saquinavir mesylate US prescribing information. Who should not take ZERIT? Mitotane: May decrease the serum concentration of CYP3A4 Substrates. Management: Doses of CYP3A4 substrates may need to be adjusted substantially when used in patients being treated with mitotane.
Take this medication exactly as prescribed. not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased. Only take medicine that your doctor has prescribed specially for you. Do not share your medicine with others. Isolates of HIV-1 with reduced susceptibility to the drug have been recovered from some patients treated with indinavir. Viral resistance was correlated with the accumulation of mutations that resulted in the expression of amino acid substitutions in the viral protease. Cersosimo MG, Lasala B, Folgar S, Micheli F "Epidural Lipomatosis Secondary to Indinavir in an HIV-Positive Patient. ZERIT will harm your unborn baby. Manidipine: CYP3A4 Inhibitors Strong may increase the serum concentration of Manidipine. Management: Consider avoiding concomitant use of manidipine and strong CYP3A4 inhibitors. If combined, monitor closely for increased manidipine effects and toxicities. Manidipine dose reductions may be required. Midazolam is extensively metabolized by CYP3A4. Do not take any other medicines without checking first with your doctor. To do so may increase the chance of side effects from indinavir or other medicines. paroxetine
Beekman SE, Henderson DK. HIV infection in healthcare workers: risks for infection and methods of prevention. Semin Dermatol. The solution may appear slightly hazy. This medication has caused very serious rarely fatal problems. In a 1997 postmarketing report, the average time to onset of protease inhibitor PI-related hyperglycemic event was 76 days. However, some cases occurred as early as 4 days after the initiation of therapy. The disorder was serious in 32 out of 83 cases, which included 27 hospitalizations and 5 incidents of diabetic ketoacidosis. HIV-negative adult subjects, unless otherwise indicated. Swollen kidneys due to blocked urine flow occurred rarely. Flynn TE, Bricker LA "Myocardial infarction in HIV-infected men receiving protease inhibitors. cheap doxylamine purchase now uk doxylamine
Prevention of pregnancy. It may also be used to regulate the menstrual cycle. It does NOT protect against HIV infection AIDS and other sexually transmitted diseases STDs. It may be used to treat certain conditions as determined by your doctor. Medication Guide for a complete list of ingredients in ONGLYZA. Henry K, Kitch D, Dube M, et al. "C-Reactive protein levels over time and cardiovascular risk in HIV-infected individuals suppressed on an indinavir-based regimen: AIDS Clinical Trials Group 5056s. What is alosetron Lotronex? Both Crixivan and atazanavir are associated with indirect unconjugated hyperbilirubinemia. Combinations of these drugs have not been studied and coadministration of Crixivan and atazanavir is not recommended. Deferasirox: May decrease the serum concentration of CYP3A4 Substrates. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Melvin AJ, Mohan KM, Manns Arcuino LA et al. Clinical, virologic and immunologic responses of children with advanced human immunodeficiency virus type 1 disease treated with protease inhibitors. Dose reduction of CRIXIVAN to 600 mg every 8 hours should be considered. ARIPiprazole: CYP3A4 Inhibitors Strong may increase the serum concentration of ARIPiprazole. Management: See full interaction monograph for details. Crystalluria and nephrolithiasis may occur during treatment with indinavir. The cumulative frequency of nephrolithiasis is substantially higher in pediatric patients 29% than in adult patients 12. No dosage adjustment is recommended based on age alone. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.
Check with your doctor right away if you have blood in your urine, nausea and vomiting, pain in the groin or genitals, or sharp back pain just below the ribs. Orlistat: May decrease the serum concentration of Antiretroviral Agents. SMX 3 times daily for 21 days. OGTT compared to control. Digestive System: liver function abnormalities; hepatitis including reports of hepatic failure see ; pancreatitis; jaundice; abdominal distention; dyspepsia. Crixivan must be taken at intervals of 8 hours. For optimal absorption, Crixivan should be administered without food but with water 1 hour before or 2 hours after a meal. The optimal dose of indinavir, when given in combination with efavirenz, is not known. Increasing the indinavir dose to 1000 mg every 8 hours does not compensate for the increased indinavir metabolism due to efavirenz. Sildenafil dose should not exceed a maximum of 25 mg in a 48-hour period in patients receiving concomitant CRIXIVAN therapy. Use with increased monitoring for adverse events. zepzip.info losartan
CYP3A4 inhibitor. Avoid concurrent use in patients with impaired hepatic or renal function. Pain or sores in the and throat may occur. CycloSPORINE Systemic: Protease Inhibitors may increase the serum concentration of CycloSPORINE Systemic. CycloSPORINE Systemic may increase the serum concentration of Protease Inhibitors. Talk with your health provider. The dosage is based on your weight, liver function, medical condition, other medications, and response to treatment. Wasmuth JC, Lambertz I, Voigt E, et al. "Maintenance of indinavir by dose adjustment in HIV-1-infected patients with indinavir-related toxicity. buy cheap lotriderm visa australia
This may not be a complete list of all interactions that may occur. Delamanid: CYP3A4 Inhibitors Strong may increase the serum concentration of Delamanid. Management: Increase electrocardiogram ECG monitoring frequency if delamanid is combined with strong CYP3A4 inhibitors because the risk for QTc interval prolongation may be increased. Continue frequent ECG assessments throughout the full delamanid treatment period. Hepatitis including cases resulting in hepatic failure and death has been reported in patients treated with Crixivan. Taking this medication will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person. Cilostazol: CYP3A4 Inhibitors Strong may increase the serum concentration of Cilostazol. Management: Consider reducing the cilostazol dose to 50 mg twice daily in adult patients who are also receiving strong inhibitors of CYP3A4. Rietsema WJ. Fever, erythroderma, abdominal pain, and renal failure following initiation of indinavir therapy. Clin Inf Dis. CloZAPine: CYP3A4 Inhibitors Strong may increase the serum concentration of CloZAPine.
Bad taste in the mouth; diarrhea; dizziness; drowsiness; headache; mild stomach pain or upset; nausea; tiredness; vomiting; weakness. Adequate hydration is recommended in all patients treated with Crixivan. Delta Coordinating Committee. Delta: a randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals. Lancet. Laboratories, Inc. September, 2016. To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports. ONGLYZA 5 mg or placebo. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase. It is unknown if this medication passes into milk. Inhibitors: raising the barrier to resistance. get hydrea online
Indinavir is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor. If you take Crixivan with RESCRIPTOR, your doctor may adjust the dose of Crixivan. DPP-4 inhibitors like ONGLYZA, may develop that can be severe. All interaction studies conducted in healthy, HIV-negative adult subjects, unless otherwise indicated. Collegeville, PA; 1999 Jul. IC 95. In general, higher levels of resistance were associated with the co-expression of greater numbers of substitutions, although their individual effects varied and were not additive. At least 3 amino acid substitutions must be present for phenotypic resistance to indinavir to reach measurable levels. Read the Guide provided by your before you start using and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Discuss the risks and benefits with your doctor. Alitretinoin Systemic: CYP3A4 Inhibitors Strong may increase the serum concentration of Alitretinoin Systemic. Management: Consider reducing the alitretinoin dose to 10 mg when used together with strong CYP3A4 inhibitors. Brinzolamide: CYP3A4 Inhibitors Strong may increase the serum concentration of Brinzolamide. Arminio Monforte A, Testa L, Gianotto M, Gori A, Franzetti F, Sollima S, Bini T, Moroni M "Indinavir-related alopecia. azathioprine
Ribociclib: CYP3A4 Inhibitors Strong may increase the serum concentration of Ribociclib. Management: Avoid use of ribociclib with strong CYP3A4 inhibitors when possible; if combined use cannot be avoided, reduce ribociclib dose to 400 mg once daily. Follow your doctor's instructions to examine your breasts, and report any lumps to your doctor immediately. Since this drug can be absorbed through the and and may harm an unborn baby, women who are or who may become pregnant should not handle this medication or breathe the dust from the tablets. CHILDREN or before the patient's first menstrual period; safety and effectiveness in children have not been confirmed. Registered trademark of Pfizer, Inc. Fugh-Berman A. Herb-drug interactions. Lancet. Bach MC, Godofsky EW. Indinavir nephrolithiasis in warm climates. J Acquired Immune Defic Syndr Human Retrovirol. As your gets stronger, it can begin to fight off infections you already had, possibly causing disease symptoms to come back. You could also have symptoms if your immune system becomes overactive. This reaction may happen at any time soon after starting or many months later. Take indinavir by mouth on an empty stomach at least 1 hour before or 2 hours after eating. You may also take it with a light meal that is low in calories, fat, and protein. Take indinavir with water. You may also take it with other liquids such as skim or nonfat milk, juice, coffee, or tea. HIV-1 with reduced susceptibility to indinavir have been selected in vitro and have emerged during therapy with the drug. Wintergerst U, Hoffman F, Solder B et al. Comparison of two antiretroviral triple combinations including the protease inhibitor indinavir in children infected with human immunodeficiency virus. Administration with a high fat, high calorie diet resulted in a reduction in AUC and in maximum serum concentration 77% and 84% respectively; lighter meal resulted in little or no change in these parameters. Benperidol: CYP3A4 Inhibitors Strong may increase the serum concentration of Benperidol. Patients experienced relief of symptoms upon discontinuation of the medication. Atovaquone undergoes enterohepatic cycling and primarily hepatic excretion. Use caution in patients with severe impairment; monitor closely. ZERIT stavudine should be avoided.
Indinavir is metabolized by and inhibits CYP450 3A4 isoenzymes and may potentially interact with many drugs. Symptoms may continue or worsen following discontinuation of therapy. Registered trademark of Ortho Pharmaceutical Corporation. Abbott Laboratories. Norvir ritonavir tablets and oral solution prescribing information. North Chicago, IL; 2012 Feb. Theophylline Derivatives: Protease Inhibitors may decrease the serum concentration of Theophylline Derivatives. Exceptions: Dyphylline. It is not known whether Crixivan is dialyzable by peritoneal or hemodialysis. Szczech LA "Hypertension and medication-related renal dysfunction in the HIV-infected patient. Dosage reduction for midazolam should be considered, especially if more than a single dose of midazolam is administered. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. During postmarketing experience, the interstitial nephritis continued in some patients after stopping indinavir. The highest doses in these studies produced systemic exposures in these species comparable to or slightly greater than human exposure. No treatment-related external, visceral, or skeletal changes were observed in rabbits or dogs. No treatment-related external or visceral changes were observed in rats. Treatment-related increases over controls in the incidence of supernumerary ribs at exposures at or below those in humans and of cervical ribs at exposures comparable to or slightly greater than those in humans were seen in rats. Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Gerberding J. Is antiretroviral treatment after percutaneous HIV exposure justified? Filter solution; wash bottle and filter with 6 mL purified water; cool solution to room temperature. Hispanic or Latino ethnicity. purchase now nizoral uk
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Therefore, get medical help right away if you develop any rash. ONGLYZA 5 mg group and 5 units for the placebo group. Hyperglycemia, new-onset diabetes mellitus, or exacerbation of preexisting diabetes mellitus reported with use of PIs; diabetic ketoacidosis has occurred. cheap skelaxin purchase now payment
Zopiclone: CYP3A4 Inhibitors Strong may increase the serum concentration of Zopiclone. ZERIT may be taken with or without food. Ter Hofstede HJ, Koopmans PP, Burger DM "Stavudine plasma concentrations and lipoatrophy. Idelalisib: CYP3A4 Inhibitors Strong may increase the serum concentration of Idelalisib.
ONGLYZA 5 mg 13. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Clarithromycin: Protease Inhibitors may diminish the therapeutic effect of Clarithromycin. Specifically, certain protease inhibitors may decrease formation of the active 14-hydroxy-clarithromycin metabolite, which may negatively impact clarithromycin effectiveness vs. H. influenzae and other non-MAC infections. Protease Inhibitors may increase the serum concentration of Clarithromycin. Clarithromycin dose adjustment in renally impaired patients may be needed. Clarithromycin may increase the serum concentration of Protease Inhibitors. theophylline
Temsirolimus. Levels of sirolimus, the active metabolite, may be increased, likely due to inhibition of CYP-mediated metabolism. Ingestion of Crixivan with a meal high in calories, fat, and protein reduces the absorption of indinavir. NiMODipine: CYP3A4 Inhibitors Strong may increase the serum concentration of NiMODipine. Alfuzosin: Protease Inhibitors may increase the serum concentration of Alfuzosin. Refer to the quetiapine prescribing information for recommendations on adverse reaction monitoring.